Immunity is based on a complex and diffuse system of interacting cells whose net output is greater than the sum of its parts. Our present knowledge of human immunology builds primarily on studies done in mice in which individual system components were studied in isolation. Attempts to translate this fractured knowledge to the clinic have for the most part been unsuccessful. Thus, despite its importance to our wellbeing, the immune system is virtually absent from medicine as practiced today.
Our lab’s research combines experimental & computational approaches to quantitavely study the immune system as a whole (Systems Immunology) and invetigate three main themes, spanning between clinical and basic research and tackling these problems on multiple fronts.